ABCG2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BZ16338-50, BZ16338-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: Q9UNQ0

Host: Rabbit

Reactivity: Human

Applications: WB, IHC-P, ELISA

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000

Background: ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 72 kDa; Observed MW: 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of ABCG2 in various lysates using ABCG2 antibody., Western blot analysis of ABCG2 in various lysates using ABCG2 antibody., Western blot analysis of ABCG2 in HT-29 lysates using ABCG2 antibody, Immunohistochemistry analysis of paraffin-embedded Human brain using ABCG2 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Sample with blocking peptide on the right.

Alternative Name: ABCG2; ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD338

Immunogen: The antiserum was produced against synthesized peptide derived from human ABCG2. AA range:289-338

Conjugate: Unconjugated

Modification: Unmodified